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Buy GW-501516 (Cardarine). PPARδ Agonist. [>99.8% Purity].
Inactive Ingredients: Solvent, preservative.
GW-501516 (Cardarine) is a PPARδ receptor agonist, also known as Endurobol. Based on available research, GW-501516 (Cardarine) has shown to accelerate metabolic rate, and subsequently, increase lipolysis. GW-501516 (Cardarine) was created in the 1990s. GW-501516 (Cardarine) binds to and activates the peroxisome proliferator activator receptor delta (PPAR-delta). A variety of PPAR-delta is inside the skeletal muscle tissues, and activation of this receptor affects genes related to improved metabolic function and increased physical capacity.
Peroxisome proliferator-activated receptor 8 (PPAR8) stimulation or over-expression in adipocytes leads to increased fatty acid oxidation, improved exercise tolerance, and resistance to obesity. GW-501516 is the first highly selective synthetic PPAR8 agonist available. GW-501516 binds to human PPAR8 with an IC50 value of 1 nM and is at least 100-fold selective fo1 PPAR8 compared to PPARa and PPARy .2 In obese primates, GW-501516 increases high-density lipoprotein cholesterol and apolipoprotein A-1 specific reverse cholesterol transport.
In currently available rat studies, binding of GW-501516 (Cardarine) to PPARδ promotes the recruitment of the co-activator PGC-1α. This PPARδ and co-activator complex, when active, up-regulates the expression of proteins involved in the process of energy expenditure. Similar studies performed in rats shown that GW-501516 (Cardarine) caused an increase in fatty acid metabolism in skeletal muscle tissue. When further studies were performed in primates, GW-501516 had shown to increase HDL (high-density lipoprotein) and simultaneously lower VLDL (very-low-density lipoprotein)
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